Mapping the genetic locus implicated in cytoadherence of Plasmodium falciparum to melanoma cells.

@article{Barnes1994MappingTG,
  title={Mapping the genetic locus implicated in cytoadherence of Plasmodium falciparum to melanoma cells.},
  author={Debra A. Barnes and Jenny Thompson and Tony Triglia and Karen P. Day and David J. Kemp},
  journal={Molecular and biochemical parasitology},
  year={1994},
  volume={66 1},
  pages={21-9}
}
Many lines of Plasmodium falciparum undergo a deletion of the right end of chromosome 9 during in vitro cultivation accompanied by loss of cytoadherence to melanoma cells. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting that PfEMP1 or a regulatory gene controlling PfEMP1 expression is encoded in this region. Initially a library of short fragments highly enriched for the right arm of chromosome 9 was constructed in bacteriophage lambda… CONTINUE READING
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