Mapping the genetic determinants of human immunodeficiency virus type 2 for cell tropism and replication efficiency

@article{Kawamura1998MappingTG,
  title={Mapping the genetic determinants of human immunodeficiency virus type 2 for cell tropism and replication efficiency},
  author={Meiko Kawamura and Reika Shimano and Takashi Ogasawara and Ritsuko Inubushi and Kazushi Amano and Hirofumi Akari and Ayumi Adachi},
  journal={Archives of Virology},
  year={1998},
  volume={143},
  pages={513-521}
}
Two distinct infectious molecular clones of human immunodeficiency type 2 (HIV-2) were analyzed for their biological properties in six cell lines. Fourteen chimeric and ten mutant viruses were constructed from these two viral genomes to localize the genetic determinants responsible for the phenotypes. Growth property of the viruses in the cell lines, together with the biochemical data, showed that a major determinant for the viral tropism resides in the env gene. In addition, in some cell lines… CONTINUE READING
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