Mapping the genetic determinants of human immunodeficiency virus type 2 for cell tropism and replication efficiency

  title={Mapping the genetic determinants of human immunodeficiency virus type 2 for cell tropism and replication efficiency},
  author={M. Kawamura and R. Shimano and T. Ogasawara and R. Inubushi and K. Amano and H. Akari and A. Adachi},
  journal={Archives of Virology},
  • M. Kawamura, R. Shimano, +4 authors A. Adachi
  • Published 1998
  • Biology, Medicine
  • Archives of Virology
  • SummaryTwo distinct infectious molecular clones of human immunodeficiency type 2 (HIV-2) were analyzed for their biological properties in six cell lines. Fourteen chimeric and ten mutant viruses were constructed from these two viral genomes to localize the genetic determinants responsible for the phenotypes. Growth property of the viruses in the cell lines, together with the biochemical data, showed that a major determinant for the viral tropism resides in the env gene. In addition, in some… CONTINUE READING
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