Mapping the dominant wound healing and soft tissue regeneration QTL in MRL × CAST

  title={Mapping the dominant wound healing and soft tissue regeneration QTL in MRL × CAST},
  author={Hongrun Yu and S. Mohan and G. Masinde and D. Baylink},
  journal={Mammalian Genome},
We have used a mouse ear punch model and the QTL (quantitative trait loci) mapping technique to identify genes that are responsible for soft tissue regeneration. In the early studies, we have identified several QTL and have shown that the inheritance of ear healing was additive in one cross (MRL × SJL), and recessive in another cross (DBA × 129). Because CAST mice are genetically distinct and have a different genetic background, CAST would facilitate the identification of common and novel QTL… Expand
Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping
  • Hongrun Yu, D. Baylink, +5 authors S. Mohan
  • Biology, Medicine
  • Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2007
Genetic loci that regulate healing and regeneration in LG/J and SM/J mice
Mapping of the chromosome 17 BMD QTL in the F2 male mice of MRL/MpJ × SJL/J
Regenerative phenotype in mice with a point mutation in transforming growth factor β type I receptor (TGFBR1)
Characterizing regeneration in the vertebrate ear


Regeneration in MRL mice: further genetic loci controlling the ear hole closure trait using MRL and M.m. Castaneus mice
Sexually dimorphic genes regulate healing and regeneration in MRL mice
Genetic control of the rate of wound healing in mice
Genetic analysis of a mammalian wound-healing trait.
Spallanzani's mouse: a model of restoration and regeneration.
Chromosomal regions harboring genes for the work to femur failure in mice
Experimental strategies for the genetic dissection of complex traits in animal models