Mapping the domain structure of the influenza A virus polymerase acidic protein (PA) and its interaction with the basic protein 1 (PB1) subunit.

@article{Guu2008MappingTD,
  title={Mapping the domain structure of the influenza A virus polymerase acidic protein (PA) and its interaction with the basic protein 1 (PB1) subunit.},
  author={Tom S. Y. Guu and Liping Dong and Pernilla Wittung-Stafshede and Yizhi Jane Tao},
  journal={Virology},
  year={2008},
  volume={379 1},
  pages={135-42}
}
The influenza A virus polymerase consists of three subunits (PA, PB1, and PB2) necessary for viral RNA synthesis. The heterotrimeric polymerase complex forms through PA interacting with PB1 and PB1 interacting with PB2. PA has been shown to play critical roles in the assembly, catalysis, and nuclear localization of the polymerase. To probe the structure of PA, we isolated recombinant PA from insect cells. Limited proteolysis revealed that PA contained two domains connected by a 20-residue… CONTINUE READING
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Mutational analysis of the influenza virus A/Victoria/3/75 PA protein: studies of interaction with PB1 protein and identification of a dominant negative mutant

  • T. Zurcher, S. de la Luna, J. J. Sanz-Ezquerro, A. Nieto, J. Ortin
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