Mapping the cytochrome C folding landscape.

  title={Mapping the cytochrome C folding landscape.},
  author={Julia G Lyubovitsky and Harry B. Gray and Jay R Winkler},
  journal={Journal of the American Chemical Society},
  volume={124 19},
The solution to the riddle of how a protein folds is encoded in the conformational energy landscape for the constituent polypeptide. Employing fluorescence energy transfer kinetics, we have mapped the S.cerevisiae iso-1 cytochrome c landscape by monitoring the distance between a C-terminal fluorophore and the heme during folding. Within 1 ms after denaturant dilution to native conditions, unfolded protein molecules have evolved into two distinct and rapidly equilibrating populations: a… CONTINUE READING

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