Mapping the conformational itinerary of β-glycosidases by X-ray crystallography

Abstract

The conformational agenda harnessed by different glycosidases along the reaction pathway has been mapped by X-ray crystallography. The transition state(s) formed during the enzymic hydrolysis of glycosides features strong oxocarbenium-ion-like character involving delocalization across the C-1–O-5 bond. This demands planarity of C-5, O-5, C-1 and C-2 at or… (More)

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Cite this paper

@inproceedings{Davies2003MappingTC, title={Mapping the conformational itinerary of β-glycosidases by X-ray crystallography}, author={Graham J. Davies}, year={2003} }