Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.

@article{Lian2000MappingTB,
  title={Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.},
  author={Lu Yun Lian and Igor Barsukov and Alexander P Golovanov and David R. Hawkins and Ramin Badii and Kong Hung Sze and Nicholas H Keep and Gary M. Bokoch and Gordon C. K. Roberts},
  journal={Structure},
  year={2000},
  volume={8 1},
  pages={47-55}
}
BACKGROUND Members of the Rho family of small GTP-binding proteins, such as Rho, Rac and Cdc42, have a role in a wide range of cell responses. These proteins function as molecular switches by virtue of a conformational change between the GTP-bound (active) and GDP-bound (inactive) forms. In addition, most members of the Rho and Rac subfamilies cycle between the cytosol and membrane. The cytosolic guanine nucleotide dissociation inhibitors, RhoGDIs, regulate both the GDP/GTP exchange cycle and… CONTINUE READING

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