Mapping the active site of papain with the aid of peptide substrates and inhibitors.

@article{Berger1970MappingTA,
  title={Mapping the active site of papain with the aid of peptide substrates and inhibitors.},
  author={A. Berger and Israel Schechter},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1970},
  volume={257 813},
  pages={
          249-64
        }
}
  • A. Berger, I. Schechter
  • Published 1970
  • Chemistry, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
The active site of an enzyme performs the twofold function of binding a substrate and catalysing a reaction. [...] Key Method In the present series of investigations on proteolytic enzymes, our approach is to compare the activity of the enzyme towards ( a ) peptides of increasing length, ( b ) diastereoisomeric pairs of peptides in which a particular amino acid residue has been replaced by its antipode, and ( c ) pairs of substrates in which a particular side chain (say a methyl group) has been replaced by…Expand
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