Mapping the Structural Core of Human Cerebral Cortex

@article{Hagmann2008MappingTS,
  title={Mapping the Structural Core of Human Cerebral Cortex},
  author={Patric Hagmann and Leila Cammoun and Xavier Gigandet and Reto A Meuli and Christopher John Honey and Van J. Wedeen and Olaf Sporns},
  journal={PLoS Biology},
  year={2008},
  volume={6}
}
Structurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. By using diffusion spectrum imaging, we noninvasively mapped these pathways within and across cortical hemispheres in individual human participants. An analysis of the resulting large-scale structural brain networks reveals a structural core within posterior medial and parietal cerebral cortex, as well as several distinct temporal… 

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References

SHOWING 1-10 OF 64 REFERENCES
Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex.
TLDR
A strong relationship between structure and function in medial frontal cortex is demonstrated and a strategy for testing such correspondences elsewhere in the brain is offered.
Small-world anatomical networks in the human brain revealed by cortical thickness from MRI.
TLDR
This study investigated large-scale anatomical connection patterns of the human cerebral cortex using cortical thickness measurements from magnetic resonance images and showed that the human brain anatomical network had robust small-world properties with cohesive neighborhoods and short mean distances between regions that were insensitive to the selection of correlation thresholds.
Identification and Classification of Hubs in Brain Networks
TLDR
This study presents an approach to the identification and classification of putative hub regions in brain networks on the basis of multiple network attributes and charts potential links between the structural embedding of such regions and their functional roles.
Functional connectivity in the resting brain: A network analysis of the default mode hypothesis
TLDR
This study constitutes, to the knowledge, the first resting-state connectivity analysis of the default mode and provides the most compelling evidence to date for the existence of a cohesive default mode network.
Mapping Human Whole-Brain Structural Networks with Diffusion MRI
TLDR
Based on diffusion MRI, this work proposes an efficient methodology to generate large, comprehensive and individual white matter connectional datasets of the living or dead, human or animal brain, which enables us to study the basic and potentially complex network properties of the entire brain.
Organization, development and function of complex brain networks
A Resilient, Low-Frequency, Small-World Human Brain Functional Network with Highly Connected Association Cortical Hubs
TLDR
It is concluded that correlated, low-frequency oscillations in human fMRI data have a small-world architecture that probably reflects underlying anatomical connectivity of the cortex, and could provide a physiological substrate for segregated and distributed information processing.
The connectional organization of the cortico-thalamic system of the cat.
TLDR
An extensive collation of connection tracing studies revealed approximately 1500 extrinsic connections between the cortical areas and thalamic nuclei of the cat cerebral hemisphere, and the organization of the entire cortico-thalamic network was investigated.
Comparative mapping of higher visual areas in monkeys and humans
...
...