Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel

@inproceedings{Wu2016MappingTI,
  title={Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel},
  author={Bo Wu and Bin Fang Wu and Yinglu Feng and Jiahui Tao and Yazhong Ji},
  booktitle={Scientific reports},
  year={2016}
}
The potassium channel Kv 1.3 plays a vital part in the activation of T lymphocytes and is an attractive pharmacological target for autoimmune diseases. BmP02, a 28-residue peptide isolated from Chinese scorpion (Buthus martensi Karsch) venom, is a potent and selective Kv1.3 channel blocker. However, the mechanism through which BmP02 recognizes and inhibits the Kv1.3 channel is still unclear. In the present study, a complex molecular model of Kv1.3-BmP02 was developed by docking analysis and… CONTINUE READING

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