Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

@inproceedings{Nevozhay2012MappingTE,
  title={Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit},
  author={Dmitry Nevozhay and Rhys M. Adams and Elizabeth Van Itallie and Matthew R. Bennett and G{\'a}bor Bal{\'a}zsi},
  booktitle={PLoS Computational Biology},
  year={2012}
}
Gene expression actualizes the organismal phenotypes encoded within the genome in an environment-dependent manner. Among all encoded phenotypes, cell population growth rate (fitness) is perhaps the most important, since it determines how well-adapted a genotype is in various environments. Traditional biological measurement techniques have revealed the connection between the environment and fitness based on the gene expression mean. Yet, recently it became clear that cells with identical genomes… CONTINUE READING
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