Mapping the BKCa Channel's “Ca2+ Bowl”

@article{Bao2004MappingTB,
  title={Mapping the BKCa Channel's “Ca2+ Bowl”},
  author={Lin Bao and Christina Kaldany and Ericka C. Holmstrand and Daniel H. Cox},
  journal={The Journal of General Physiology},
  year={2004},
  volume={123},
  pages={475 - 489}
}
There is controversy over whether Ca(2+) binds to the BK(Ca) channel's intracellular domain or its integral-membrane domain and over whether or not mutations that reduce the channel's Ca(2+) sensitivity act at the point of Ca(2+) coordination. One region in the intracellular domain that has been implicated in Ca(2+) sensing is the "Ca(2+) bowl". This region contains many acidic residues, and large Ca(2+)-bowl mutations eliminate Ca(2+) sensing through what appears to be one type of high… CONTINUE READING

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