Mapping the Antigenic and Genetic Evolution of Influenza Virus

@article{Smith2004MappingTA,
  title={Mapping the Antigenic and Genetic Evolution of Influenza Virus},
  author={Derek J. Smith and Alan S. Lapedes and Jan C. de Jong and Theo M. Bestebroer and Guus F Rimmelzwaan and Albert D M E Osterhaus and Ron A. M. Fouchier},
  journal={Science},
  year={2004},
  volume={305},
  pages={371 - 376}
}
The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains… Expand
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References

SHOWING 1-10 OF 57 REFERENCES
Antigenic and genetic evolution of equine H3N8 influenza A viruses.
TLDR
It was noted that antigenic and genetic variants of equine H3N8 viruses cocirculate, and in particular that variants currently circulating in Europe and the USA are distinguishable from one another both in terms of antigenic reactivity and genetic structure of the haemagglutinin (HA) molecule. Expand
Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus
TLDR
A method for predicting future dominant HA amino acid sequences is introduced and its potential relevance to vaccine choice is discussed, as well as the relationship between cluster structure and the primary antibody-combining regions of the HA protein. Expand
The evolution of human influenza viruses.
The evolution of influenza viruses results in (i) recurrent annual epidemics of disease that are caused by progressive antigenic drift of influenza A and B viruses due to the mutability of the RNAExpand
Ecological and immunological determinants of influenza evolution
TLDR
By matching model output to phylogenetic patterns seen in sequence data collected through global surveillance, it is found that short-lived strain-transcending immunity is essential to restrict viral diversity in the host population and thus to explain key aspects of drift and shift dynamics. Expand
Predicting the evolution of human influenza A.
TLDR
Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift. Expand
Positive selection on the H3 hemagglutinin gene of human influenza virus A.
The hemagglutinin (HA) gene of influenza viruses encodes the major surface antigen against which neutralizing antibodies are produced during infection or vaccination. We examined temporal variationExpand
The total influenza vaccine failure of 1947 revisited: Major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic
TLDR
Although the 1947 epidemic lacked the usual hallmarks of pandemic disease, it warns of the possibility that extreme intrasubtypic antigenic variation (if coupled with an increase in disease severity) could producePandemic disease without the introduction of animal virus antigens. Expand
Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites
TLDR
The data reveal the existence of multiple evolutionary pathways during at least one period of development of the H3N2 (Hong Kong) influenza virus subtype and strikingly demonstrate that amino acid changes are limited to a small number of locations on the HA molecule during antigenic drift. Expand
Unifying the Epidemiological and Evolutionary Dynamics of Pathogens
TLDR
A phylodynamic framework for the dissection of dynamic forces that determine the diversity of epidemiological and phylogenetic patterns observed in RNA viruses of vertebrates is introduced. Expand
Mapping of antigenic changes in the haemagglutinin of Hong Kong influenza (H3N2) strains using a large panel of monoclonal antibodies.
  • P. Underwood
  • Biology, Medicine
  • The Journal of general virology
  • 1982
A panel of 125 monoclonal antibodies (IgG) was raised against the haemagglutinin of an early representative of the Hong Kong (H3N2) subtype of influenza. They were classified into groups based onExpand
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