Mapping the Antigenic and Genetic Evolution of Influenza Virus

  title={Mapping the Antigenic and Genetic Evolution of Influenza Virus},
  author={D. Smith and A. Lapedes and J. D. de Jong and T. Bestebroer and G. Rimmelzwaan and A. Osterhaus and R. Fouchier},
  pages={371 - 376}
  • D. Smith, A. Lapedes, +4 authors R. Fouchier
  • Published 2004
  • Biology, Medicine
  • Science
  • The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains… CONTINUE READING

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    The evolution of human influenza viruses.
    • 422
    Unifying the Epidemiological and Evolutionary Dynamics of Pathogens
    • 995
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