Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers

@inproceedings{ZulianiAlvarez2017MappingTI,
  title={Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers},
  author={Lorena Zuliani-Alvarez and Anna M. Marzeda and Claire Deligne and Anja Schwenzer and Fiona E McCann and Brian D. Marsden and Anna M Piccinini and Kim S. Midwood},
  booktitle={Nature Communications},
  year={2017}
}
Pattern recognition underpins innate immunity; the accurate identification of danger, including infection, injury, or tumor, is key to an appropriately targeted immune response. Pathogen detection is increasingly well defined mechanistically, but the discrimination of endogenous inflammatory triggers remains unclear. Tenascin-C, a matrix protein induced upon tissue damage and expressed by tumors, activates toll-like receptor 4 (TLR4)-mediated sterile inflammation. Here we map three sites within… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS