Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

@inproceedings{Hefendehl2016MappingSG,
  title={Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging},
  author={Jasmin K Hefendehl and Jeff M. LeDue and Rebecca W Y Ko and Jasmin Mahler and Timothy H. Murphy and Brian A MacVicar},
  booktitle={Nature communications},
  year={2016}
}
Amyloid-β (Aβ) plaques, a hallmark of Alzheimer's disease (AD), are surrounded by regions of neuronal and glial hyperactivity. We use in vivo two-photon and wide-field imaging of the glutamate sensor iGluSnFR to determine whether pathological changes in glutamate dynamics in the immediate vicinity of Aβ deposits in APPPS1 transgenic mice could alter neuronal activity in this microenvironment. In regions close to Aβ plaques chronic states of high spontaneous glutamate fluctuations are observed… CONTINUE READING
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