Mapping quantitative trait loci with censored observations.

  title={Mapping quantitative trait loci with censored observations.},
  author={Guoqing Diao and D. Y. Lin and Fei Zou},
  volume={168 3},
The existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and is fully observed. These assumptions may not be satisfied when the phenotype pertains to the survival time or failure time, which has a skewed distribution and is usually subject to censoring due to random loss of follow-up or limited duration of the experiment. In this article, we propose an interval-mapping approach for censored failure time phenotypes. We… CONTINUE READING

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Multiple genetic loci modify susceptibility to plas - mapping for quantitative trait loci

E. S. Lander, D. Botstein
Genetics • 2002

A statistical framework of quanti - et al . , 1991 Genetic mapping of a gene causing hypertension in the stroke - prone spontaneously hypertensive rat . Cell 67 : 213 – tative trait mapping

R. C. Jansen

Theoretical basis of precision mapping of quantita - Lehmann , E . L . , 1975 Nonparametrics : Statistical Methods Based on tive trait loci

Z-B. Zeng
Proc . Natl . Acad . Sci . USA • 1993
View 1 Excerpt

Hypothesis testing when a nuisance parameter is present only under the alternative

R. B. Davies
Biometrika Stat . Sci . • 1977
View 1 Excerpt

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