Mapping quantitative trait loci with censored observations.

@article{Diao2004MappingQT,
  title={Mapping quantitative trait loci with censored observations.},
  author={Guoqing Diao and D. Y. Lin and Fei Zou},
  journal={Genetics},
  year={2004},
  volume={168 3},
  pages={1689-98}
}
The existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and is fully observed. These assumptions may not be satisfied when the phenotype pertains to the survival time or failure time, which has a skewed distribution and is usually subject to censoring due to random loss of follow-up or limited duration of the experiment. In this article, we propose an interval-mapping approach for censored failure time phenotypes. We… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

Multiple genetic loci modify susceptibility to plas - mapping for quantitative trait loci

E. S. Lander, D. Botstein
Genetics • 2002

A statistical framework of quanti - et al . , 1991 Genetic mapping of a gene causing hypertension in the stroke - prone spontaneously hypertensive rat . Cell 67 : 213 – tative trait mapping

R. C. Jansen
2001

Theoretical basis of precision mapping of quantita - Lehmann , E . L . , 1975 Nonparametrics : Statistical Methods Based on tive trait loci

Z-B. Zeng
Proc . Natl . Acad . Sci . USA • 1993
View 1 Excerpt

Hypothesis testing when a nuisance parameter is present only under the alternative

R. B. Davies
Biometrika Stat . Sci . • 1977
View 1 Excerpt

Similar Papers

Loading similar papers…