Mapping of two immunodominant antigenic epitopes conserved among the major inner capsid protein, VP7 of five bluetongue viruses.

@article{Li1990MappingOT,
  title={Mapping of two immunodominant antigenic epitopes conserved among the major inner capsid protein, VP7 of five bluetongue viruses.},
  author={Joseph K-K Li and Young Yell Yang},
  journal={Virology},
  year={1990},
  volume={178 2},
  pages={552-9}
}
A combination of polyclonal, monoclonal, and oligoclonal antibodies was used in Western blot to analyze intact VP7 proteins and their proteolytic peptide fragments of five bluetongue viruses found in the United States. Two linear immunodominant antigenic determinants were located and identified on this major inner capsid protein. One of the antigenic epitopes, which consisted of 11 residues (LTRAIARAAYV), was mapped by polyclonal antibody to the carboxyl terminus of the viral protein (residues… CONTINUE READING

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