Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genome.

@article{Lamb1980MappingOT,
  title={Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genome.},
  author={Robert A. Lamb and Purnell W. Choppin and Robert M. Chanock and C J Lai},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 4},
  pages={1857-61}
}
RNA segment 8 of the influenza virus genome is unique in coding for two polypeptides, NS1 (Mr, approximately 25,000) and NS2 (Mr, approximately 11,000). These polypeptides are synthesized from separate mRNA species. By using cloned DNA derived from RNA segment 8 (NS DNA) the two mRNAs have been mapped on segment 8 by hybridization of mRNAs with restriction endonuclease fragments of the DNA and nuclease S1 digestion methods. These data indicate that the body of the NS1 mRNA (approximately 850… CONTINUE READING

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