Mapping of the thymidine kinase genes of type 1 and type 2 herpes simplex viruses using intertypic recombinants.

@article{Halliburton1980MappingOT,
  title={Mapping of the thymidine kinase genes of type 1 and type 2 herpes simplex viruses using intertypic recombinants.},
  author={I. W. Halliburton and Lawrence S. Morse and Bernard Roizman and Kathleen Quinn},
  journal={The Journal of general virology},
  year={1980},
  volume={49 2},
  pages={
          235-53
        }
}
The thymidine kinase induced in lytic infection by each of 36 intertypic recombinants of herpes simplex virus (HSV) type 1 and type 2 was identified as type 1 or type 2 by studies on the thermolability of enzyme activity, neutralization with type 1 or type 2 antiserum and agar gel immunodiffusion with type 1 or type 2 thymidine kinase antiserum. Fourteen recombinants induced no thymidine kinase, 12 induced type 1 thymidine kinase and 10 induced type 2 thymidine kinase. Correlation of these… 

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