Mapping of the regions involved in homotypic interactions of Tula hantavirus N protein.

@article{Kaukinen2003MappingOT,
  title={Mapping of the regions involved in homotypic interactions of Tula hantavirus N protein.},
  author={Pasi Kaukinen and Antti Vaheri and Alexander Plyusnin},
  journal={Journal of virology},
  year={2003},
  volume={77 20},
  pages={10910-6}
}
Hantavirus nucleocapsid (N) protein has been suggested to form homodimers and homotrimers that are further integrated into the nucleocapsid filaments around the viral RNA. Here we report detailed mapping of the regions involved in the homotypic N protein interactions in Tula hantavirus (TULV). Peptide scan screening was used to define the interaction regions, and the mammalian two-hybrid assay was used for the functional analysis of N protein mutants. To study linear regions responsible for N… CONTINUE READING
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