Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis.

@article{Skeldal2012MappingOT,
  title={Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis.},
  author={Sune Skeldal and Alex M. Sykes and Simon Glerup and Dusan Matusica and Nickless Palstra and Henri Autio and Zoran Boskovic and Peder Madsen and Eero Castr{\'e}n and Anders Nykjaer and Elizabeth J. Coulson},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 52},
  pages={43798-809}
}
Neurotrophins comprise a group of neuronal growth factors that are essential for the development and maintenance of the nervous system. However, the immature pro-neurotrophins promote apoptosis by engaging in a complex with sortilin and the p75 neurotrophin receptor (p75(NTR)). To identify the interaction site between sortilin and p75(NTR), we analyzed binding between chimeric receptor constructs and truncated p75(NTR) variants by co-immunoprecipitation experiments, surface plasmon resonance… CONTINUE READING

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NUMBER 52 JOURNAL OF BIOLOGICAL CHEMISTRY 43809 at U Q L irary on Sptem er 1, 2016 hp://w w w .jb.org/ D

A. M. Sykes, N. Palstra, +6 authors E. J. Coulson
J. Biol. Chem • 2012

Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2011

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