Mapping of the human tuftelin (TUFT1) gene to Chromosome 1 by fluorescence in situ hybridization

@article{Deutsch2004MappingOT,
  title={Mapping of the human tuftelin (TUFT1) gene to Chromosome 1 by fluorescence in situ hybridization},
  author={Dan Deutsch and Aaron Palmon and Marian F. Young and Sara Selig and William G. Kearns and Larry W. Fisher},
  journal={Mammalian Genome},
  year={2004},
  volume={5},
  pages={461-462}
}
1Dental Research Unit, Hebrew University Hadassah School of Dental Medicine, P.O. Box 1172, Jerusalem, Israel 91010 2Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA 3Department of Cellular Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel 91010 4John Hopkins University School of Medicine, Center for Medical Genetics, Baltimore, Maryland 21205, USA 
The Human Tuftelin Gene and the Expression of Tuftelin in Mineralizing and Nonmineralizing Tissues
TLDR
These results and earlier Northern blot results show that tuftelin, in addition to being expressed in the developing and mineralizing tooth, is also expressed in several nonmineralizing soft tissues, suggesting that tuftselin has a universal function and/or a multifunctional role.
Candidate-gene exclusion in a family with inherited non-syndromic dental disorders.
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Results indicate that mutation p.Asp243Asn is a highly probable cause of non-syndromic dental disorder in this Chinese family and the clinical classification system is hampered by the lack of close correlation between the subtype and the molecular defect.
The genetics of odontogenesis: implications in dental anthropology and palaeo-odontology
TLDR
Combining the genetics of odontogenesis with forensic evidence and palaeoanthropological fossil data provides an unparalleled source of information on heredity, environmental and evolutionary events through teeth, the most durable of all biological structures after death.
The Genetics of Odontogenesis: Implications in Dental Anthropology and Palæo-Odontology
TLDR
Combining the genetics of odontogenesis with forensic evidence and palaeoanthropological fossil data provides an unparalled source of information on heredity, environmental and evolutionary events through teeth, the most durable of all biological structures after death.
High yield expression of biologically active recombinant full length human tuftelin protein in baculovirus-infected insect cells.
TLDR
The hypothesis that tuftelin plays an important role during embryogenesis is supported by the findings of this study.
Biphasic influence of hypoxia on tuftelin expression in mouse mesenchymal C3H10T1/2 stem cells.
TLDR
The hypothesis that oxygen stress modulates tuftelin 1 expression in relation to HIF-1-alpha (Hif1a) is investigated, in a mouse mesenchymal C3H10T1/2 stem cell model, and it is proposed that tuFTelin is a member of oxygen-sensitive genes and implicated in the adaptive mechanisms regulating MSC function.
The genetic basis of inherited anomalies of the teeth. Part 1: clinical and molecular aspects of non-syndromic dental disorders.
TLDR
The genetic basis of inherited anomalies describes the molecular bases and clinical features of inherited non-syndromic teeth disorders and focuses on genetic syndromes with dental involvement.
Gene evolution and functions of extracellular matrix proteins in teeth
TLDR
The recently defined terms matrisome and matrixome for ECMs, as well as focus on genes and functions of enamel and dentin matrix proteins, play important roles in cell adhesion, polarity, and differentiation and mineralization ofEnamel and Dentin matrices.
TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling
TLDR
It is shown that tuftelin 1 (TUFT1) was involved in the activation of mTORC1 through modulating the Rab GTPase-regulated process and suggested that it is a promising therapeutic target or a biomarker for tumor progression.
Tuft protein: protein cross-linking in enamel development.
TLDR
Tuft protein may be a mechanism to prevent protein degradation at the enamel-dentine junction during the degradation of enamel matrix, which occurs during amelogenesis.
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References

SHOWING 1-10 OF 11 REFERENCES
Rapid subchromosomal localization of cosmids by nonradioactive in situ hybridization.
TLDR
A rapid method for localizing large numbers of complete cosmids by nonradioactive in situ hybridization is described, achieving rapid identification of chromosome 16 by cohybridization with a chromosome 16-specific centromeric repeat probe.
Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3.
TLDR
The PXMP1 gene was assigned to human chromosome 1p21-p22 by in situ hybridization and its murine homologue (Pxmp-1) to chromosome 3 by interspecific backcross analysis.
Sequencing of bovine enamelin ("tuftelin") a novel acidic enamel protein.
TLDR
The immunological techniques were employed using antibodies directed against synthetic peptides corresponding to the protein sequence deduced from the cloned cDNA sequence, and the results reveal the deduced protein to be a novel acidic enamel protein.
Structure and function of enamel gene products
  • D. Deutsch
  • Biology, Medicine
    The Anatomical record
  • 1989
The present paper reviews the main features of amelogenin and enamelin biochemistry, molecular biology, structural and ultrastructural localization, and immunology. It also examines recent studies
A human gene responsible for Zellweger syndrome that affects peroxisome assembly.
TLDR
A human complementary DNA has been cloned that complements the disease's symptoms (including defective peroxisome assembly) in fibroblasts from a patient with Zellweger syndrome.
Enamelin and Enameloid
TLDR
This finding, that enameloid mineralization occurs in the presence of enamel ins but does not require the existence of amelogenins, is indicative of the important biological role of these proteins.
Properties of dissociatively extracted fetal tooth matrix proteins. I. Principal molecular species in developing bovine enamel.
TLDR
In fetal bovine enamel, the initial dissociative extraction step completely removes proline-rich amelogenins from the tissue without dissolving the enamel apatite, and gel filtration data showed a clear shift in molecular size population from higher to lower components for both amelgenins and enamelins with progressive enamel maturation.
Localization of the 70kDa peroxisomal membrane protein to human lp21-p22 and mouse
  • Genomics
  • 1993
Cloning , sequencing , and characterization of tuftelinnovel acidic enamel protein
  • Connect . Tissue Res .
  • 1992
Mapping the human tnftelin gene to Chr 1 M.F
  • Connect. Tissue Res
  • 1992
...
1
2
...