Mapping of the human complement factor I gene to 4q25.

  title={Mapping of the human complement factor I gene to 4q25.},
  author={Rita Shiang and Jeffrey C Murray and Cynthia C Morton and Kenneth H. Buetow and John Jacob Wasmuth and Ann Haskins Olney and Warren G. Sanger and Gabriel Goldberger},
  volume={4 1},
A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and… CONTINUE READING