Mapping of the beta 2-adrenoceptor on Chang liver cells. Differences between high- and low-affinity receptor states.

Receptor mapping procedures based on the methodology of Crippen are used to study the beta 2-adrenergic receptor system in intact Chang liver cells. In cases of agonists, the presence of both a low- and high-affinity receptor state is assumed, whereas antagonists bind to the low-affinity state only. The high-affinity state is considered to contain the… CONTINUE READING