Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer.

@article{Tang2012MappingOT,
  title={Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer.},
  author={Wei Tang and Yi-ping Fu and Jonine D Figueroa and N{\'u}ria Malats and Montserrat Garc{\'i}a-Closas and Nilanjan Chatterjee and Manolis Kogevinas and Dalsu Baris and Michael J. Thun and Jennifer Hall and Immaculata De Vivo and Demetrius Albanes and Patricia A Porter-Gill and Mark P Purdue and Laurie A. Burdett and Luyang Liu and Amy Hutchinson and Timothy S. Myers and Adonina Tard{\'o}n and Consol Serra and Alfredo Carrato and Reina Garc{\'i}a-Closas and Josep Lloreta and Alison Venable Johnson and Molly Schwenn and Margaret R. Karagas and Alan R. Schned and Amanda Black and Eric J Jacobs and W Ryan Diver and Susan M. Gapstur and Jarmo R Virtamo and David J. Hunter and Joseph F. Jr. Fraumeni and Stephen J. Chanock and Debra T. Silverman and Nathaniel Rothman and Ludmila Prokunina-Olsson},
  journal={Human molecular genetics},
  year={2012},
  volume={21 8},
  pages={
          1918-30
        }
}
A recent genome-wide association study of bladder cancer identified the UGT1A gene cluster on chromosome 2q37.1 as a novel susceptibility locus. The UGT1A cluster encodes a family of UDP-glucuronosyltransferases (UGTs), which facilitate cellular detoxification and removal of aromatic amines. Bioactivated forms of aromatic amines found in tobacco smoke and industrial chemicals are the main risk factors for bladder cancer. The association within the UGT1A locus was detected by a single nucleotide… CONTINUE READING
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