Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor.

@article{Blin1995MappingOS,
  title={Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor.},
  author={Nikolaus Blin and Jong Hoon Yun and Juergen Wess},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 30},
  pages={
          17741-8
        }
}
Each G protein-coupled receptor can interact only with a limited number of the many structurally similar G proteins expressed within a cell. This study was undertaken to identify single amino acids required for selectively coupling the m3 muscarinic acetylcholine receptor to G proteins of the Gq/11 family. To this goal, distinct intracellular segments/amino acids of the m3 receptor were systematically substituted into the structurally closely related m2 muscarinic receptor, which couples to Gi… CONTINUE READING
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