Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3

@article{Simmonds1993MappingOS,
  title={Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3},
  author={P. Simmonds and K. Rose and S. Graham and S. Chan and F. Mcomish and B. Dow and E. Follett and P. Yap and H. Marsden},
  journal={Journal of Clinical Microbiology},
  year={1993},
  volume={31},
  pages={1493 - 1503}
}
The effect of sequence variability between different types of hepatitis C virus (HCV) on the antigenicity of the NS-4 protein was investigated by epitope mapping and by enzyme-linked immunosorbent assay with branched oligopeptides. Epitope mapping of the region between amino acid residues 1679 and 1768 in the HCV polyprotein revealed two major antigenic regions (1961 to 1708 and 1710 to 1728) that were recognized by antibody elicited upon natural infection of HCV. The antigenic regions were… Expand
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