Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology.

@article{Pasternak1995MappingOO,
  title={Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology.},
  author={Gavril W Pasternak and Kelly M. Standifer},
  journal={Trends in pharmacological sciences},
  year={1995},
  volume={16 10},
  pages={344-50}
}
Understanding the pharmacology of opioid receptors took a major step forward with the cloning of genes that encode four members of the opioid receptor family. Gavril Pasternak and Kelly Standifer show how strategies that use antisense oligodeoxynucleotides can provide a selective approach to correlate the properties of the cloned receptors with their in vivo pharmacological effects, and have confirmed the association of the delta-, mu- and kappa 1-opioid receptor clones with analgesia mediated… CONTINUE READING