Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.

@article{Kloeting1998MappingON,
  title={Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.},
  author={Ingrid Kloeting and Sabine S. Schmidt and Peter Kovacs},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={245 2},
  pages={483-6}
}
By several crossing studies it has been demonstrated that the MHC class-II genes of the RT1u haplotype, Iddm1, and the lymphopenia, Iddm2, are essential, but not sufficient for diabetes development in the BB rat. Using diabetic BB/OK and diabetes-resistant DA rats it has been shown that a third non-MHC gene, Iddm3, on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Because mapping results need not be consistent among different crosses, we genetically analysed a new cross… CONTINUE READING