Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system

@article{Kow1998MappingON,
  title={Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system},
  author={Lee-ming Kow and Donald W. Pfaff},
  journal={Behavioural Brain Research},
  year={1998},
  volume={92},
  pages={169-180}
}
  • L. Kow, D. Pfaff
  • Published 1 May 1998
  • Medicine, Biology
  • Behavioural Brain Research
46 – Estrogen Regulation of Neurotransmitter and Growth Factor Signaling in the Brain
TLDR
It is concluded that estrogen acts throughout the central nervous system (CNS) to modulate neuronal excitability and synaptic efficacy, suggesting that this is a fundamental mechanism of steroid-hormone action in the brain.
Estrogen Regulation of Neurotransmitter and Growth Factor Signaling in the Brain
TLDR
The data show that estrogens act throughout the brain to modulate neuronal excitability, synaptic efficacy, and neurogenesis, suggesting that these are fundamental mechanisms of steroid hormone action in the brain.
Cell type-specificity of nonclassical estrogen signaling in the developing midbrain
TLDR
The major conclusion drawn from studies is that estrogens interact with yet unidentified membrane receptor complexes which stimulate the phospholipase C and induce the formation of inosite-tri-phosphate (IP(3), which causes a rapid and transitory rise in intracellular free calcium.
Effects of estrogens and progesterone on the synaptic organization of the hypothalamic ventromedial nucleus
TLDR
From the sex steroids that undergo cyclic variations over the estrous cycle, only estrogens, acting through both ERalpha and ERbeta, play a key role in the activation of the neural circuits involving the ventromedial nucleus of the hypothalamus.
Sex and estrogenic effects on coexpression of mRNAs in single ventromedial hypothalamic neurons.
TLDR
The basis for systematic linkage of the brain's hormone-sensitive signaling pathways to biophysical and behavioral mechanisms in a well studied mammalian system is established.
Estrogenic Regulation of Histamine Receptor Subtype H1 Expression in the Ventromedial Nucleus of the Hypothalamus in Female Rats
TLDR
Investigation of the relationship between estrogen and histamine receptor subtype H1 (H1R), which is a potent subtype among histamine receptors in the brain, suggests that estrogen can amplify histamine signaling by enhancing H1R expression in the vl VMN.
Androgen receptors are required for full masculinization of nitric oxide synthase system in rat limbic–hypothalamic region
TLDR
The data indicate that, contrary to current opinions, androgens, through the action of AR may have a relevant role in the organization and modulation of the nNOS hypothalamic system.
Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats.
TLDR
Findings indicate that rapid membrane ERalpha-mGluR1a interactions activate PKCtheta cell signaling, which regulates female sexual receptivity.
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It is shown that estradiol is also selectively cytotoxic to beta-endorphin neurons in the hypothalamic arcuate nucleus, which may contribute to a number of reproductive disorders in humans and in animals in which aberrant hypothalamic function is a major component.
Selective brain stem transections affecting reproductive behavior of female rats: The role of hypothalamic output to the midbrain
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The observation of intermittent lordotic responses, or improved lordotic behavior following additional treatment with estrogen and/or progesterone revealed that these laterally transected animals were still able to produce the motor pattern of lordosis.
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Electrophysiological studies indicate that the most likely place where sensory inputs from cutaneous touch-pressure receptors interact with estrogen-influenced neural activity to elicit the reflex is the spinal cord itself.
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TLDR
There is at present no basis to conclude that the effects of pharmacological manipulations of serotonergic activity on lordosis reflect an important, physiological role of 5-HT in the modulation of lordosis behavior in the female rat.
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This review summarizes data from the author's laboratory on three topics: actions of extradiol and progesterone on the ventromedial nucleus of the hypothalamus in adult female and male rats, showing both the cyclicity and the consequences of brain sexual differentiation.
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A phorbol ester, TPA, was used to activate a key enzyme, protein kinase C (PKC), of the PI pathway in ovariectomized (OVX) rats either primed or not primed with estrogen, and direct activation of this pathway can potentiate the behavior.
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Studies of the action of steroid honnones on the brain have progressed to a point where specific mechanisms and brain sites of action are now recognized, and especially important to the neurophannacologist are aspects of mechanism which have begun to deal with hormonal modifica­ tion of properties and functions of synapses.
Electrophysiological analyses of serotonergic actions on neurons in hypothalamic ventromedial nucleus in vitro: receptor subtypes involved and implications for regulation of feeding and lordosis behaviors.
TLDR
It emerges from the findings that the inhibitory action of 5-HT on VMN neurons is associated with, and may be responsible for, the stimulation of feeding and inhibition of lordosis, while the excitatory action is related and may lead to the opposite behavioral effects.
Covergent effects of lordosis-relevant somatosensory and hypothalamic influences on central gray cells in the rat mesencephalon
TLDR
Central gray neurons recorded here, probably short-axoned, may help to integrate hypothalamic outputs with somatosensory influences on natural behavior patterns, including lordosis in the female rat.
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