Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system

@article{Kow1998MappingON,
  title={Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system},
  author={Lee-ming Kow and Donald W. Pfaff},
  journal={Behavioural Brain Research},
  year={1998},
  volume={92},
  pages={169-180}
}
  • L. Kow, D. Pfaff
  • Published 1 May 1998
  • Medicine, Biology
  • Behavioural Brain Research
View on Elsevier
doi.org
114 Citations
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Background Citations
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114 Citations

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References

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It is shown that estradiol is also selectively cytotoxic to beta-endorphin neurons in the hypothalamic arcuate nucleus, which may contribute to a number of reproductive disorders in humans and in animals in which aberrant hypothalamic function is a major component.
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The observation of intermittent lordotic responses, or improved lordotic behavior following additional treatment with estrogen and/or progesterone revealed that these laterally transected animals were still able to produce the motor pattern of lordosis.
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Electrophysiological studies indicate that the most likely place where sensory inputs from cutaneous touch-pressure receptors interact with estrogen-influenced neural activity to elicit the reflex is the spinal cord itself.
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TLDR
There is at present no basis to conclude that the effects of pharmacological manipulations of serotonergic activity on lordosis reflect an important, physiological role of 5-HT in the modulation of lordosis behavior in the female rat.
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This review summarizes data from the author's laboratory on three topics: actions of extradiol and progesterone on the ventromedial nucleus of the hypothalamus in adult female and male rats, showing both the cyclicity and the consequences of brain sexual differentiation.
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TLDR
A phorbol ester, TPA, was used to activate a key enzyme, protein kinase C (PKC), of the PI pathway in ovariectomized (OVX) rats either primed or not primed with estrogen, and direct activation of this pathway can potentiate the behavior.
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Electrophysiological analyses of serotonergic actions on neurons in hypothalamic ventromedial nucleus in vitro: receptor subtypes involved and implications for regulation of feeding and lordosis behaviors.
TLDR
It emerges from the findings that the inhibitory action of 5-HT on VMN neurons is associated with, and may be responsible for, the stimulation of feeding and inhibition of lordosis, while the excitatory action is related and may lead to the opposite behavioral effects.
Covergent effects of lordosis-relevant somatosensory and hypothalamic influences on central gray cells in the rat mesencephalon
TLDR
Central gray neurons recorded here, probably short-axoned, may help to integrate hypothalamic outputs with somatosensory influences on natural behavior patterns, including lordosis in the female rat.
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