Mapping of human X-linked hypophosphataemic rickets by multilocus linkage analysis

  title={Mapping of human X-linked hypophosphataemic rickets by multilocus linkage analysis},
  author={Andrew P. Read and Rajesh V Thakker and K. E. Davies and Roger C. Mountford and David P. Brenton and Michael P H Davies and Francis H Glorieux and Rodney Harris and Geoffrey N Hendy and Andrew King and Susan McGlade and Craig Peacock and Raffaella Smith and Jeffrey L. H. O'Riordan},
  journal={Human Genetics},
Eleven families with X-linked dominant hypophosphataemic rickets (HPDR) have been typed for a series of X chromosome markers. Linkage with probe 99.6 (DXS41) was demonstrated with a peak lod score of 4.82 at 10% recombination. Multilocus linkage analysis showed that HPDR maps distal to 99.6; this probe has previously been located at Xp22.31-p21.3 by in situ hybridisation. In the mouse hypophosphataemia (Hyp) maps to the distal part of the X chromosome; our location in man is consistent with a… CONTINUE READING


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1 Excerpt

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