Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet v 1.

@article{Gieras2011MappingOC,
  title={Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet v 1.},
  author={Anna Gieras and Petra Cejka and Katharina Blatt and Margarete Focke-Tejkl and Birgit Linhart and Sabine Flicker and Angelika Stoecklinger and Katharina Marth and Anja Drescher and Josef Thalhamer and Peter Valent and Otto Majdic and Rudolf Valenta},
  journal={Journal of immunology},
  year={2011},
  volume={186 9},
  pages={
          5333-44
        }
}
Allergic inflammation is based on the cross-linking of mast cell and basophil-bound IgE Abs and requires at least two binding sites for IgE on allergens, which are difficult to characterize because they are often conformational in nature. We studied the IgE recognition of birch pollen allergen Bet v 1, a major allergen for >100 million allergic patients. Monoclonal and polyclonal Abs raised against Bet v 1-derived peptides were used to compete with allergic patients' IgE binding to Bet v 1 to… CONTINUE READING

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