Mapping of balanced chromosome translocation breakpoints to the basepair level from microdissected chromosomes

@article{Obenauf2010MappingOB,
  title={Mapping of balanced chromosome translocation breakpoints to the basepair level from microdissected chromosomes},
  author={A. C. Obenauf and T. Schwarzbraun and Martina Auer and E. M. Hoffmann and Julie Waldispuehl-Geigl and Peter Ulz and B. Guenther and H. Duba and M. Speicher and J. Geigl},
  journal={Journal of Cellular and Molecular Medicine},
  year={2010},
  volume={14},
  pages={2078 - 2084}
}
  • A. C. Obenauf, T. Schwarzbraun, +7 authors J. Geigl
  • Published 2010
  • Biology, Medicine
  • Journal of Cellular and Molecular Medicine
  • The analysis of structural variants associated with specific phenotypic features is promising for the elucidation of the function of involved genes. There is, however, at present no approach allowing the rapid mapping of chromosomal translocation breakpoints to the basepair level from a single chromosome. Here we demonstrate that we have advanced both the microdissection and the subsequent unbiased amplification to an extent that breakpoint mapping to the basepair level has become possible. As… CONTINUE READING
    6 Citations

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