Mapping of a quantitative trait locus for morphine withdrawal severity


Chronic morphine exposure results in physical dependence, manifested by physical symptoms during naloxone-precipitated withdrawal. Jumping frequency is widely considered the most sensitive and reliable index of withdrawal intensity in mice. Inbred mouse strains surveyed for naloxone-precipitated withdrawal display large and significant strain differences in… (More)
DOI: 10.1007/s00335-004-2367-3


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