Mapping of a new locus for congenital anomalies of the kidney and urinary tract on chromosome 8q24.

@article{Ashraf2010MappingOA,
  title={Mapping of a new locus for congenital anomalies of the kidney and urinary tract on chromosome 8q24.},
  author={Shazia Ashraf and Bethan E. Hoskins and Hassan Chaib and Julia Hoefele and Andreas Pasch and Pawaree Saisawat and Friedrich Trefz and Hans W. Hacker and Gudrun Nuernberg and Peter N{\"u}rnberg and Edgar A. Otto and Friedhelm Hildebrandt},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2010},
  volume={25 5},
  pages={1496-501}
}
BACKGROUND Congenital anomalies of the kidney and urinary tract (CAKUT) account for the majority of end-stage renal disease in children (50%). Previous studies have mapped autosomal dominant loci for CAKUT. We here report a genome-wide search for linkage in a large pedigree of Somalian descent containing eight affected individuals with a non-syndromic form of CAKUT. METHODS Clinical data and blood samples were obtained from a Somalian family with eight individuals with CAKUT including high… CONTINUE READING

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