Mapping of a fusion related epitope of the respiratory syncytial virus fusion protein.

@article{Paradiso1991MappingOA,
  title={Mapping of a fusion related epitope of the respiratory syncytial virus fusion protein.},
  author={Peter R. Paradiso and Brian Hu and R. Arumugham and Stephen W. Hildreth},
  journal={Vaccine},
  year={1991},
  volume={9 4},
  pages={
          231-7
        }
}
The region of the fusion glycoprotein of respiratory syncytial virus which reacts with a neutralizing and fusion inhibiting monoclonal antibody, was mapped using a deductive method derived from analysis of Western blot reactivity of proteolytic fragments. Reaction of the whole fusion protein was found to be so conformationally dependent, that complete digestion of the protein with a variety of proteases resulted in fragments which were not sufficiently reactive to permit mapping. For this… CONTINUE READING