Mapping of a de novo unequal crossover causing a deletion of the steroid 21-hydroxylase (CYP21A2) gene and a non-functional hybrid tenascin-X (TNXB) gene.

Abstract

In the human genome, the major histocompatibility complex class III region on chromosome 6p21.3 stands out as an area of remarkably high gene density. 2 Within this region, a section of particular complexity centres around the C4 genes, which encode the fourth component of complement. Centromeric to C4 lies the CYP21A2 gene, which encodes steroid 21… (More)

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