Mapping of Mycobacterium tuberculosis katG promoters and their differential expression in infected macrophages.

@article{Master2001MappingOM,
  title={Mapping of Mycobacterium tuberculosis katG promoters and their differential expression in infected macrophages.},
  author={Sharon Master and Thomas C. Zahrt and Jongwoo Song and Vojo Deretic},
  journal={Journal of bacteriology},
  year={2001},
  volume={183 13},
  pages={4033-9}
}
Intracellular pathogenic bacteria, including Mycobacterium tuberculosis, frequently have multitiered defense mechanisms ensuring their survival in host phagocytic cells. One such defense determinant in M. tuberculosis is the katG gene, which encodes an enzyme with catalase, peroxidase, and peroxynitritase activities. KatG is considered to be important for protection against reactive oxygen and nitrogen intermediates produced by phagocytic cells. However, KatG also activates the front-line… CONTINUE READING

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