Mapping of IgE binding regions in the major rat urinary protein, alpha 2u-globulin, using overlapping peptides.

@article{Bayard1999MappingOI,
  title={Mapping of IgE binding regions in the major rat urinary protein, alpha 2u-globulin, using overlapping peptides.},
  author={C C Bayard and Abu Bakar Siddique and Klavs Berzins and Marita Troye-Blomberg and Ulf Hellman and Olof Vesterberg},
  journal={Immunological investigations},
  year={1999},
  volume={28 5-6},
  pages={323-38}
}
Exposure to laboratory animals poses a hazard for development of occupational allergy. Identification of antigenic determinants of allergenic proteins may be valuable for immunotherapeutic purposes. Overlapping peptides of the major allergen in rat urine, Rat n 1.02, corresponding to the protein alpha2u-globulin were synthesised on solid support and screened simultaneously to locate IgE binding linear epitopes using a simple modified ELISA procedure. Thirty-nine peptides were synthesised, each… CONTINUE READING

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