Mapping of Genotype–Phenotype Diversity among Clinical Isolates of Mycobacterium tuberculosis by Sequence-Based Transcriptional Profiling

@inproceedings{Rose2013MappingOG,
  title={Mapping of Genotype–Phenotype Diversity among Clinical Isolates of Mycobacterium tuberculosis by Sequence-Based Transcriptional Profiling},
  author={Graham Rose and Teresa Romero Cort{\'e}s and I{\~n}aki Comas and Mireia Coscolla and S{\'e}bastien Gagneux and Douglas Brownlee Young},
  booktitle={Genome biology and evolution},
  year={2013}
}
Genome sequencing has identified an extensive repertoire of single nucleotide polymorphisms among clinical isolates of Mycobacterium tuberculosis, but the extent to which these differences influence phenotypic properties of the bacteria remains to be elucidated. To determine whether these polymorphisms give rise to phenotypic diversity, we have integrated genome data sets with RNA sequencing to assess their impact on the comparative transcriptome profiles of strains belonging to M. tuberculosis… CONTINUE READING