Mapping of Functional Subdomains in the Terminal Protein Domain of Hepatitis B Virus Polymerase.


Hepatitis B virus (HBV) encodes a multifunction reverse transcriptase or polymerase (P), which is composed of several domains. The terminal protein (TP) domain is unique to HBV and related hepadnaviruses and is required for specifically binding to the viral pregenomic RNA (pgRNA). Subsequently, the TP domain is necessary for pgRNA packaging into viral… (More)
DOI: 10.1128/JVI.01785-16