Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups.

  title={Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups.},
  author={Frank Courjal and Marguerite Cuny and Jo{\"e}lle Simony-Lafontaine and G. Louason and Paul Speiser and Robert Zeillinger and Carmen Arbelo Rodr{\'i}guez and Charles Theillet},
  journal={Cancer research},
  volume={57 19},
DNA amplification is frequent in breast cancer and has been associated with specific clinicopathological parameters and/or worsened course of the disease. In the present work, we were interested in further defining the association linking the occurrence of DNA amplification to the emergence of specific breast tumor phenotype. To this aim, we studied by Southern blotting a total of 1875 breast tumor DNAs with 26 probes mapping at 15 distinct chromosomal localizations. Of the 26 loci tested, 11… CONTINUE READING


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