Mapping of Behaviour in Drosophila Mosaics
@article{Hotta1972MappingOB, title={Mapping of Behaviour in Drosophila Mosaics}, author={Yoshiki Hotta and Seymour Benzer}, journal={Nature}, year={1972}, volume={240}, pages={527-535} }
By making genetic mosaics and constructing embryonic “fate maps” it is possible to locate the anatomical site of abnormalities affecting behaviour.
338 Citations
Fate mapping of nervous system and other internal tissues in genetic mosaics of Drosophila melanogaster.
- BiologyDevelopmental biology
- 1976
The effort to make mosaic analysis a household tool
- BiologyDevelopment
- 2012
Improve the methods used to make genetic mosaics in Drosophila by taking advantage of recently developed approaches for genome engineering, which led to the work described in the 1993 Development paper.
A computer program automating construction of fate maps of Drosophila.
- Computer ScienceDevelopmental biology
- 1976
Morphogenetic fate map of prospective adult structures of the honey bee.
- Biology, MedicineDevelopmental biology
- 1976
Genetics of the nervous system in Drosophila.
- BiologyQuarterly reviews of biophysics
- 1982
The genetic analysis of Drosophila neurobiology has expanded into a considerable field. A host of genetic variants is now available for analyzing the development, structure, physiology, and chemistry…
Early developmental subdivisions of the wing disk in Drosophila
- BiologyMolecular and General Genetics MGG
- 2004
It appears that this mutation interferes with a step leading to normal wing-notum compartmentation of the wing disk, and therefore mutations in this gene can be autonomous in mosaics.
Molecular genetic analysis of muscle development, structure, and function in Drosophila.
- BiologyInternational review of cytology
- 1993
Maximum likelihood estimates for fate map locations of behavior in Drosophila.
- MathematicsDevelopmental biology
- 1974
Fate-mapping in wild-typeDrosophila melanogaster
- BiologyWilhelm Roux's archives of developmental biology
- 2004
SummaryThe pattern of cell proliferation and cell movements inDrosophila embryogenesis has been analysed with the aim of constructing a blastoderm fate map. Post-blastoderm cell proliferation starts…
Mosaic analysis of lethal mutations in Drosophila.
- BiologyGenetics
- 1973
The effects of various lethal mutations were studied when they were present in the hemizygous state as sectors in genetic mosaics (gynandromorphs) of Drosophila melanogaster to identify the regions affected by these lethals.
References
SHOWING 1-10 OF 27 REFERENCES
Genetics: Genetic Analysis of Developmental Mechanisms in Drosophila
- BiologyNature
- 1971
The fruit fly Drosophila is being increasingly used in embryological experiments because of its well known genetics, and the ease of manipulation, it provides an ideal system for following such processes as cellular determination during differentiation, and cloning in morphogenesis.
Genetic dissection of the Drosophila nervous system by means of mosaics.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1970
Mutants of five different genes on the X-chromosome of Drosophila melanogaster, having various abnormalities in visual function, have been tested and all have been found to be autonomous, indicating that the primary causes of the behavioral deficits in these mutants are within the eye.
Determination of blastoderm cells in Drosophila melanogaster.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1971
A method for culturing blastoderm cells of Drosophila in vivo has been developed that allows these cells to differentiate into larval or adult structures and the specificity of determination and the localization of determinative factors is discussed.
Cleavage Patterns in Drosophila and Mosaic Formation
- Biology
- 1936
The study of the early developmental history of Drosophila melanogaster from the fertilization of the egg to the end of gastrulation, has been undertaken to lay an embryological foundation which might serve as a means of interpreting the conditions found in various types of gynandromorphs and mosaics.
Unilaterally patterned neural activity of gynandromorphs, mosaic for a neurological mutant of Drosophila melanogaster.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1970
A neurophysiological study of a behavioral phenotype caused by a sex-linked single gene mutation has been performed with gynandromorphs, mosaic for the mutant gene, Hyperkinetic(1P) (Hk(1P)), in…
Cell lineage of the imaginal discs in Drosophila gynandromorphs.
- BiologyThe Journal of experimental zoology
- 1969
A collection of 379 drawings of D. simulans claret gynandromorphs was used in order to analyze the cell lineage of the adult cuticular structures and the marker phenotypes forked bristles or yellow body color were used to trace the male tissue.
Certain aspects of cell lineage and morphogenesis studied in embryos of Drosophila melanogaster with an ultra-violet micro-beam.
- BiologyJournal of embryology and experimental morphology
- 1961
Egg irradiation with ultra-violet light was particularly suitable for this type of work because of its comparatively low penetration into protoplasm: roughly 85 per cent, absorption occurred in 50 μ at a wavelength of 300 mμ and stronger absorption was obtained at shorter wavelengths.
Patterned neural activity of a mutant Drosophila melanogaster.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1970
Hyperkinetic (1P), a behavioral mutant of Drosophila melanogaster, shows rhythmic leg-shaking action derived from mutation of a single, sex-linked gene that was independent both of sensory information and higher centers in the central nervous system but endogenous within the ganglion.
Circadian clock mutants of Drosophila melanogaster
- Biology
- 1972
Evidence is presented that Pittendrigh's two-oscillator model for the clock in D. melanogaster applies to pseudoobscura and the arrhythmic mutation appears to have eliminated the driving oscillator while leaving the temperature-sensitive driven oscillator relatively intact.
BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTION.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1967
Drosophila offers the same advantages to such a study as it did to classical genetics, namely, large numbers and short generation time, to which may now be added an enormous store of accumulated knowledge concerning the organism.