Mapping neutralizing and non-neutralizing epitopes on the capsid protein of feline calicivirus.

@article{Geissler2002MappingNA,
  title={Mapping neutralizing and non-neutralizing epitopes on the capsid protein of feline calicivirus.},
  author={Kyleigh A Geissler and Klaus Schneider and Uwe Truyen},
  journal={Journal of veterinary medicine. B, Infectious diseases and veterinary public health},
  year={2002},
  volume={49 1},
  pages={55-60}
}
Neutralizing epitopes on feline calicivirus (FCV) capsid protein were mapped using chimeric capsid proteins recombinant between two FCV isolates that do not show any cross-neutralization. The three chimeric proteins examined were expressed in murine L929 cells employing an MVA/T7 vaccinia virus expression system and inoculated into major histocompatibility complex haplotype-matched C3/HN mice. Based on the neutralizing antibody titre the neutralizing epitope(s) could be mapped to the 5… CONTINUE READING