Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

  title={Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C},
  author={Borbala Mifsud and Filipe Tavares-Cadete and Alice N C Young and Robert Sugar and Stefan Schoenfelder and Lauren F Ferreira and Steven W Wingett and Simon R. Andrews and William Grey and Philip A Ewels and Bram Herman and Scott Happe and Andy Higgs and Emily M. LeProust and George Alexander Follows and Peter Fraser and Nicholas M. Luscombe and Cameron S. Osborne},
  journal={Nature Genetics},
Transcriptional control in large genomes often requires looping interactions between distal DNA elements, such as enhancers and target promoters. Current chromosome conformation capture techniques do not offer sufficiently high resolution to interrogate these regulatory interactions on a genomic scale. Here we use Capture Hi-C (CHi-C), an adapted genome conformation assay, to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types. We identify over 1.6 million… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 76 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 174 extracted citations


Publications referenced by this paper.
Showing 1-10 of 40 references

A high-resolution map of the three-dimensional chromatin interactome in human cells

  • F Jin
  • Nature 503,
  • 2013

Similar Papers

Loading similar papers…