Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation.

@article{Kong2014MappingKR,
  title={Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation.},
  author={Roy C. K. Kong and Ross A D Bathgate and Shoni Bruell and John D Wade and Paul R. Gooley and Emma J. Petrie},
  journal={Biochemistry},
  year={2014},
  volume={53 28},
  pages={4537-48}
}
The peptide hormone INSL3 and its receptor, RXFP2, have co-evolved alongside relaxin and its receptor, RXFP1. Both RXFP1 and RXFP2 are G protein-coupled receptors (GPCRs) containing the hallmark seven transmembrane helices in addition to a distinct ectodomain of leucine-rich repeats (LRRs) and a single low-density lipoprotein class-A (LDLa) module at the N-terminus. RXFP1 and RXFP2 are the only mammalian GPCRs known to contain an LDLa, and its removal does not perturb primary ligand binding to… CONTINUE READING
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