Mapping interactions between germinants and Clostridium difficile spores.

@article{Howerton2011MappingIB,
  title={Mapping interactions between germinants and Clostridium difficile spores.},
  author={Amber Janece Howerton and Norma Ramirez and Ernesto V. Abel-Santos},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 1},
  pages={274-82}
}
Germination of Clostridium difficile spores is the first required step in establishing C. difficile-associated disease (CDAD). Taurocholate (a bile salt) and glycine (an amino acid) have been shown to be important germinants of C. difficile spores. In the present study, we tested a series of glycine and taurocholate analogs for the ability to induce or inhibit C. difficile spore germination. Testing of glycine analogs revealed that both the carboxy and amino groups are important epitopes for… CONTINUE READING