Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.

@article{Lewis1995MappingIV,
  title={Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.},
  author={Jean M Lewis and Martin A Schwartz},
  journal={Molecular biology of the cell},
  year={1995},
  volume={6 2},
  pages={151-60}
}
Integrins promote formation of focal adhesions and trigger intracellular signaling pathways through cytoplasmic proteins such as talin, alpha-actinin, and focal adhesion kinase (FAK). The beta 1 integrin subunit has been shown to bind talin and alpha-actinin in in vitro assays, and these proteins may link integrin to the actin cytoskeleton either directly or through linkages to other proteins such as vinculin. However, it is unknown which of these associations are necessary in vivo for… CONTINUE READING

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