Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment

  title={Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment},
  author={G. Ch{\'e}telat and B. Desgranges and V. de la Sayette and F. Viader and F. Eustache and J. Baron},
We used voxel-based morphometry to comprehensively and objectively map gray matter loss in 22 patients with amnestic mild cognitive impairment, defined as progressive isolated episodic memory decline. Compared with 22 age-matched healthy controls, patients had highly significant gray matter loss predominantly affecting the hippocampal region and cingulate gyri (posterior and subcallosal part of the anterior), and extending into the temporal neocortex. Compared with 16 age-matched patients with… Expand
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Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease.
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Analysis of Gray Matter in AD Patients and MCI Subjects Based Voxel-Based Morphometry
Compared with NCs, AD patients and MCI subjects shared some abnormal brain regions such as bilateral parahippocampal gyrus, bilateral hippocampus, left amygdala and left fusiform, which provided additional evidences to support the viewpoint that MCI is the transitional stage between normal aging and AD. Expand


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